Report of the PGDIS Task Group on the status of PGT-A

Don Leigh; Richard T Scott Jr; Svetlana Rechitsky; Alan H Handyside; Santiago Munne; Dagan Wells; Joris R Vermeesch; Semra Kahraman; Luca Gianaroli; Carmen Rubio; Mandy Katz-Jaffe; David S Cram; KungPu Xu; Zi-Jian Chen; Yuan Gao; Svetlana Madjunkova; Gary Harton; Tony Gordon; Lee Shulman; Joe Leigh Simpson; Anver Kuliev; Preimplantation Genetic Diagnosis International Society, Northbrook IL, USA

doi:10.1016/j.rbmo.2026.105498

Report of the PGDIS Task Group on the status of PGT-A

Reprod Biomed Online. 2026 Jun;52(6):105498. doi: 10.1016/j.rbmo.2026.105498. Epub 2026 Jan 26.

Authors

Don Leigh¹, Richard T Scott Jr², Svetlana Rechitsky³, Alan H Handyside⁴, Santiago Munne⁵, Dagan Wells⁶, Joris R Vermeesch⁷, Semra Kahraman⁸, Luca Gianaroli⁹, Carmen Rubio¹⁰, Mandy Katz-Jaffe¹¹, David S Cram¹², KungPu Xu¹³, Zi-Jian Chen¹⁴, Yuan Gao¹⁵, Svetlana Madjunkova¹⁶, Gary Harton¹⁷, Tony Gordon¹⁸, Lee Shulman¹⁹, Joe Leigh Simpson²⁰, Anver Kuliev²¹; Preimplantation Genetic Diagnosis International Society, Northbrook IL, USA

Affiliations

¹ First People's Hospital of Kunming, Calmette Hospital, Kunming; The Reproductive Hospital of Guangxi Zhuang Autonomous Region, Guangxi; The Reproductive Health Research Center of Guangxi Zhuang Autonomous Region.
² Yale University and Foundation of Embryonic Competence, USA.
³ Reproductive Genetic Innovations, Northbrook, Illinois, USA.
⁴ ExOvo Genomics, Brighton, UK.
⁵ Overture Life.
⁶ Royal College of Obstetricians and Gynecologists, Oxford, UK.
⁷ Center for Human Genetics Leuven, Belgium.
⁸ ART & Reproductive Genetics, Istanbul Memorial Hospital, Turkey.
⁹ Luca Gianaroli Center, Bologna, Italy.
¹⁰ Igenomix, Valencia, Spain.
¹¹ Colorado Center for Reproductive Medicine, Denver, Colorado, USA.
¹² Banano, ChongQing, China.
¹³ Cornell University, New York, USA.
¹⁴ State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education; Shandong Technology Innovation Center for Reproductive Health; Shandong Provincial Clinical Research Center for Reproductive Health; Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, China; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics; Department of Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
¹⁵ State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education; Shandong Technology Innovation Center for Reproductive Health; Shandong Provincial Clinical Research Center for Reproductive Health; Shandong Key Laboratory of Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University; Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences (No.2021RU001), Jinan, Shandong, China.
¹⁶ CReATe Fertility Centre, Toronto, Ontario, Canada.
¹⁷ Eastern VA Medical School, Norfolk, Virginia, USA.
¹⁸ Cooper Genomics.
¹⁹ Northwestern University, Chicago, Illinois, USA.
²⁰ Florida International University, Miami, Florida, USA.
²¹ Reproductive Genetic Innovations, Northbrook, Illinois, USA. Electronic address: anverkuliev@hotmail.com.

PMID: 41980563
DOI: 10.1016/j.rbmo.2026.105498

Abstract

The clinical utility and validity of preimplantation genetic testing for aneuploidies (PGT-A) in IVF practice is often questioned. Some major societies (Practice Committees of the American Society for Reproductive Medicine and the Society for Assisted Reproductive Technology 2024) have released ambiguous statements about PGT-A, leaving the potential and benefits of embryo selection, enhanced by chromosome profile assessments, indeterminant. The Preimplantation Genetic Diagnosis International Society (PGDIS) Task Group has gathered the scientific information and critically evaluated the evidence about the clinical value of PGT-A. We considered technical aspects, genetic principles and clinical outcome studies, and conclude that the proper implementation of PGT-A results in increased benefits for IVF embryo selection. It is envisioned that this report will remove some of the confusion surrounding PGT-A, lead to informed choices about the use of PGT-A and ultimately result in improved transfer outcomes.

Keywords: Aneuploidy; Misconceptions of PGT-A; Preimplantation genetic testing for aneuploidies (PGT-A); Somatic mosaicism.

Publication types

Review

MeSH terms

Aneuploidy*
Female
Fertilization in Vitro
Genetic Testing*
Humans
Pregnancy
Preimplantation Diagnosis* / methods
Reproductive Techniques, Assisted