Incidental Intracranial Schwannoma With High 68 Ga-PSMA Uptake on PET/CT

Clin Nucl Med. 2026 Sep 1;51(9):e770-e771. doi: 10.1097/RLU.0000000000006449. Epub 2026 Apr 10.

Abstract

A 67-year-old man with newly diagnosed prostate adenocarcinoma underwent 68 Ga-PSMA PET/CT for initial staging. In addition to intense focal uptake in the prostate gland consistent with the primary tumor, the scan demonstrated heterogeneous PSMA uptake in the inferior-anterior region of the left temporal lobe adjacent to the left cavernous sinus. Further evaluation of this intracranial lesion with brain MRI raised a differential diagnosis between prostate cancer metastasis and cavernous sinus meningioma. Ultimately, surgical resection and histopathologic analysis established the diagnosis of schwannoma.

Keywords: schwannoma.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Biological Transport
  • Brain Neoplasms* / diagnostic imaging
  • Brain Neoplasms* / metabolism
  • Edetic Acid* / analogs & derivatives
  • Gallium Isotopes
  • Gallium Radioisotopes
  • Humans
  • Incidental Findings*
  • Male
  • Neurilemmoma* / diagnostic imaging
  • Neurilemmoma* / metabolism
  • Oligopeptides* / metabolism
  • Organometallic Compounds*
  • Positron Emission Tomography Computed Tomography*

Substances

  • Gallium Radioisotopes
  • gallium 68 PSMA-11
  • Gallium Isotopes
  • Edetic Acid
  • Oligopeptides
  • Organometallic Compounds