A 3D co-culture model with fibroblast-restricted FAP expression for cancer therapy using [212Pb]Pb-FAPI-46

Sandra K Kristiansen; Nurtene Dernjani; Øyvind S Bruland; Nina Frederike J Edin; Asta Juzeniene

doi:10.1186/s41181-026-00444-0

A 3D co-culture model with fibroblast-restricted FAP expression for cancer therapy using [²¹²Pb]Pb-FAPI-46

EJNMMI Radiopharm Chem. 2026 Apr 18. doi: 10.1186/s41181-026-00444-0. Online ahead of print.

Authors

Sandra K Kristiansen^{1

2}, Nurtene Dernjani^{1

3}, Øyvind S Bruland^{4

5}, Nina Frederike J Edin², Asta Juzeniene^{6

7}

Affiliations

¹ Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.
² Department of Physics, University of Oslo, Oslo, Norway.
³ Department of Molecular Biology, Norwegian University of Life Science, Ås, Norway.
⁴ Department of Oncology, Oslo University Hospital, Oslo, Norway.
⁵ Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
⁶ Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway. astaj@ous-hf.no.
⁷ Department of Physics, University of Oslo, Oslo, Norway. astaj@ous-hf.no.

PMID: 41998481
DOI: 10.1186/s41181-026-00444-0

No abstract available

Keywords: 212Pb; Cancer; Cancer-associated fibroblasts; Co-culture spheroids; Fibroblast activation protein; Targeted alpha therapy; Tumor microenvironment.