Female adnexal Wolffian tumors: A comparison of reported benign and malignant cases and STK11 adnexal tumors

Georgia Karpathiou; Tadao Nakazawa; Kenzo Hiroshima

doi:10.1016/j.prp.2026.156479

Female adnexal Wolffian tumors: A comparison of reported benign and malignant cases and STK11 adnexal tumors

Pathol Res Pract. 2026 Jul:283:156479. doi: 10.1016/j.prp.2026.156479. Epub 2026 Apr 20.

Authors

Georgia Karpathiou¹, Tadao Nakazawa², Kenzo Hiroshima²

Affiliations

¹ Pathology Department, University Hospital of Saint-Etienne, Saint-Etienne, France; Pathology Department, Tokyo Woman's Medical University Yachiyo Medical Center (TYMC), Chiba, Japan. Electronic address: georgia.karpathiou@chu-st-etienne.fr.
² Pathology Department, Tokyo Woman's Medical University Yachiyo Medical Center (TYMC), Chiba, Japan.

PMID: 42030651
DOI: 10.1016/j.prp.2026.156479

Abstract

Wolffian tumors of the female adnexa are rare with only few cases reported. Their benign or malignant nature is not clearly defined in the literature and many of the malignant cases are probably misdiagnoses. The description of similar tumors harboring STK11 mutations has opened new pathways in understanding these tumors. In this review, we sought to present in detail the reported FATWO and STK11 adnexal tumors to understand their clinical and pathological features, and to discuss their differential diagnosis.

Keywords: FATWO; Mesonephric; Mesothelioma; Paratubal; STK11 adnexal tumor.

Publication types

Review
Comparative Study

MeSH terms

AMP-Activated Protein Kinase Kinases
Adenoma* / genetics
Adenoma* / pathology
Adnexal Diseases* / genetics
Adnexal Diseases* / pathology
Biomarkers, Tumor / genetics
Diagnosis, Differential
Female
Humans
Protein Serine-Threonine Kinases* / genetics

Substances

Protein Serine-Threonine Kinases
AMP-Activated Protein Kinase Kinases
STK11 protein, human
Biomarkers, Tumor

Supplementary concepts

Wolffian tumor