Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate

Biochemistry. 1974 Jan 29;13(3):471-81. doi: 10.1021/bi00700a012.
No abstract available

MeSH terms

  • Chlorine / pharmacology
  • Chromatography
  • Chromatography, Ion Exchange
  • Deoxyribonucleotides / metabolism*
  • Drug Resistance, Microbial
  • Drug Stability
  • Enzyme Activation
  • Fluorine / metabolism
  • Folic Acid / pharmacology
  • Guanidines / pharmacology
  • Kinetics
  • Lactobacillus casei / enzymology
  • Methotrexate
  • Methyltransferases / metabolism*
  • Peptide Fragments
  • Pronase / pharmacology
  • Protein Binding
  • Spectrophotometry, Ultraviolet
  • Structure-Activity Relationship
  • Tetrahydrofolates / metabolism
  • Thermodynamics
  • Thymidylate Synthase / isolation & purification
  • Thymidylate Synthase / metabolism
  • Tritium
  • Uracil Nucleotides / metabolism

Substances

  • Deoxyribonucleotides
  • Guanidines
  • Peptide Fragments
  • Tetrahydrofolates
  • Uracil Nucleotides
  • Tritium
  • Fluorine
  • Chlorine
  • Folic Acid
  • Methyltransferases
  • Thymidylate Synthase
  • Pronase
  • Methotrexate