Anatomical Variations in Major Abdominal Aortic Branches and Sex-Related Differences: A Large-Scale Analysis of 1174 Patients

Tomography. 2026 Apr 6;12(4):51. doi: 10.3390/tomography12040051.

Abstract

Background: This study aims to evaluate the prevalence, spectrum, and coexistence of anatomical variations in the major branches of the abdominal aorta using Multidetector Computed Tomography (MDCT) angiography, with a specific emphasis on analyzing sex-related differences in a large-scale cohort.

Methods: A retrospective analysis was conducted on 1174 patients (63.8% male, 36.2% female; mean age 60.54) who underwent abdominal CT angiography between January 2023 and June 2024. Images were acquired using a 128-slice MDCT scanner and reconstructed for detailed vascular assessment. Statistical comparisons between genders were performed using Chi-square and Fisher-Freeman-Halton tests, with p < 0.05 considered significant.

Results: The celiac trunk (93.3%), superior mesenteric artery (SMA) (97.1%), and inferior mesenteric artery (IMA) (98.5%) predominantly showed classical patterns. However, significant sex-related differences were identified. Females exhibited significantly higher rates of classical patterns for the celiac trunk (96.2% vs. 91.7%), IMA (99.1% vs. 98.1%), right hepatic artery (RHA) (91.5% vs. 82.6%), and left hepatic artery (LHA) (95.8% vs. 85.4%). Conversely, males showed a higher prevalence of complex variations, including replaced/accessory hepatic arteries and the absence of the common hepatic artery. The number of right and left renal arteries was similar between sexes and did not show a significant difference, while horseshoe kidney was detected only in males.

Conclusions: Abdominal vascular structures adhere to classical anatomy more frequently in females, while males exhibit greater morphological variability. These findings emphasize the necessity of gender-specific preoperative vascular mapping to optimize surgical outcomes and reduce morbidity.

Keywords: abdominal aorta; anatomical variations; computed tomography angiography; sex-related differences.

MeSH terms

  • Adult
  • Aged
  • Anatomic Variation*
  • Aorta, Abdominal* / anatomy & histology
  • Aorta, Abdominal* / diagnostic imaging
  • Celiac Artery / anatomy & histology
  • Celiac Artery / diagnostic imaging
  • Computed Tomography Angiography* / methods
  • Female
  • Humans
  • Male
  • Mesenteric Artery, Superior / anatomy & histology
  • Mesenteric Artery, Superior / diagnostic imaging
  • Middle Aged
  • Multidetector Computed Tomography* / methods
  • Retrospective Studies
  • Sex Factors