Penidelanones A-F: furancarboxylic acids from the endophytic fungus Penicillium daleae

J Asian Nat Prod Res. 2026 Apr 30:1-8. doi: 10.1080/10286020.2026.2662991. Online ahead of print.

Abstract

Six new furancarboxylic acids, penidelanones A - F (1 - 6), along with one known analogue, (+)-gregatin B (7), were discovered from the endophytic fungus, Penicillium daleae. Penidelanone A (1) is the first reported furancarboxylic acid with an amide group. Their planar structures were determined by extensive spectroscopic data, and the absolute configurations were assigned by comparison of optical values.

Keywords: Furancarboxylic acids; Penicillium daleae; fungus; secondary metabolites.