Schizothorax davidi, a cold-water fish endemic to the Qinghai-Tibetan Plateau (QTP), represents an important economic resource in the upper Yangtze River. Regarded as a promising model for studying high-altitude adaptation and polyploidization, this species has still lacked a reference genome. Here, we report a haplotype-resolved, chromosome-scale genome of S.davidi (4n = 98), generated by integrating PacBio HiFi, Oxford Nanopore ultralong, and Hi-C sequencing data. The assembly spans 3.7 Gb across 98 chromosomes with a scaffold N50 of 36.93 Mb, includes 98,079 annotated protein-coding genes, and reveals large-scale regions of lost heterozygosity across 11 chromosomes. This haplotype-resolved genomic resource will advance the study of vertebrate polyploidy and adaptive evolution.
© 2026. The Author(s).