B cells gone broad: A deep dive into SARS-CoV-2 antibody breadth

Sci Immunol. 2026 May;11(119):eaei2832. doi: 10.1126/sciimmunol.aei2832. Epub 2026 May 1.

Authors

Easton E Ford¹, Melissa L Smith¹

Affiliation

¹ Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY, USA.

PMID: 42066060
DOI: 10.1126/sciimmunol.aei2832

Abstract

Antigen-specific B cell profiling uncovers key determinants of SARS-CoV-2 antibody breadth after infection and vaccination.

Publication types

Editorial
Comment

MeSH terms

Antibodies, Viral* / immunology
COVID-19 / immunology
COVID-19 Vaccines
Humans
Immunoglobulin Class Switching
Memory B Cells* / immunology
SARS-CoV-2* / immunology
Vaccination

Substances

Antibodies, Viral
COVID-19 Vaccines