Abstract
We analyse the non-steady state behaviour of a computer model representing functional epithelial cells. The results show that a simple model of an epithelium, containing the essential ion transport asymmetries of the original Koefoed-Johnsen-Ussing model, predicts much of the observed behaviour of 'tight-type' epithelia under various well characterized experimental conditions.
MeSH terms
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Amiloride / pharmacology
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Animals
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Anura
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Biological Transport / drug effects
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Cations, Monovalent / metabolism
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Cell Compartmentation
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Chlorides / metabolism
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Computers
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Epithelium / metabolism*
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Kinetics
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Membrane Potentials / drug effects
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Models, Biological
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Ouabain / pharmacology
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Skin Physiological Phenomena
Substances
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Cations, Monovalent
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Chlorides
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Ouabain
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Amiloride