Selective destruction of the pigmented epithelium in the ciliary body of the eye

Science. 1974 Jun 21;184(4143):1298-9. doi: 10.1126/science.184.4143.1298.


Perfusion of the internal carotid artery with hypertonic solution selectively destroys most of the pigmented epithelium of the ciliary body of the monkey eye, converts fenestrated endothelium of capillaries to continuous endothelium, and transiently breaks down the blood-aqueous barrier. The nonpigmented epithelium regenerates and the intraocular pressure returns to normal even though the pigmented epithelium is permanently destroyed.

MeSH terms

  • Amides
  • Animals
  • Aqueous Humor / physiology*
  • Carotid Artery, Internal
  • Ciliary Body / blood supply
  • Ciliary Body / cytology
  • Ciliary Body / physiology*
  • Epithelial Cells
  • Epithelium / physiology
  • Haplorhini
  • Hypertonic Solutions
  • Intraocular Pressure*
  • Lactates
  • Macaca
  • Ophthalmic Artery
  • Perfusion
  • Pigmentation
  • Urea


  • Amides
  • Hypertonic Solutions
  • Lactates
  • Urea