Inhaled anti-thymic stromal lymphopoietin antibody fragment, ecleralimab, in severe asthma: A placebo-controlled, multicenter, double-blind, randomized, phase 2b clinical trial
Am J Respir Crit Care Med
.
2026 Jul 1;212(7):1617-1620.
doi: 10.1093/ajrccm/aamag123.
Authors
Alexander J Mackay
1
,
Christian Gessner
2
3
,
Horacio Budani
4
,
Steven Weinstein
5
,
Yasushi Fukushima
6
,
Erika A Zannou-Mantri
7
,
Ilias Stavropoulos
8
,
James M Felser
7
,
Keroles Nakhla
7
,
Peter D'Andrea
7
,
Xintong Chen
7
,
Paul M O'Byrne
9
Affiliations
1
Novartis Pharma AG, Basel, Switzerland.
2
Department of Clinical Immunology, University Hospital Leipzig, Leipzig, Germany.
3
POIS Leipzig GbR, Leipzig, Germany.
4
Respiratory Area of the Foundation for Clinical Assistance and Research in Prevalent Diseases (FAICEP), Buenos Aires, Argentina.
5
Allergy and Asthma Specialists Medical Group and Research Center, Huntington Beach, CA, United States.
6
Fukuwa Clinic, Tokyo, Japan.
7
Novartis Pharmaceuticals Corporation, East Hanover, NJ, United States.
8
Novartis Ireland Limited, Dublin, Ireland.
9
Department of Medicine, McMaster University, Hamilton, ON, Canada.
PMID:
42085310
PMCID:
PMC13322294
DOI:
10.1093/ajrccm/aamag123
No abstract available
Keywords:
Asthma; Human TSLP; Lung function.
Grants and funding
Novartis Pharma AG