Local anaesthetic pharmacokinetics of single-injection erector spinae plane block: systematic review of pharmacokinetic studies

Alessandro De Cassai; Burhan Dost; Yunus E Karapinar; Esra Turunc; Engin I Turan; Annalisa Boscolo

doi:10.1016/j.bja.2026.03.062

Local anaesthetic pharmacokinetics of single-injection erector spinae plane block: systematic review of pharmacokinetic studies

Br J Anaesth. 2026 Jul;137(1):289-292. doi: 10.1016/j.bja.2026.03.062. Epub 2026 May 8.

Authors

Alessandro De Cassai¹, Burhan Dost², Yunus E Karapinar³, Esra Turunc², Engin I Turan⁴, Annalisa Boscolo⁵

Affiliations

¹ Department of Medicine (DIMED), University of Padua, Padua, Italy; Institute of Anesthesia and Intensive Care, University Hospital of Padua, Padua, Italy. Electronic address: alessandro.decassai@unipd.it.
² Department of Anesthesiology and Reanimation, Faculty of Medicine, Ondokuz Mayis University, Samsun, Türkiye.
³ Department of Anesthesiology and Reanimation, Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Türkiye.
⁴ Department of Anesthesiology and Reanimation, Istanbul Kanuni Sultan Süleyman Education and Training Hospital, Health Science University, Istanbul, Türkiye.
⁵ Department of Medicine (DIMED), University of Padua, Padua, Italy; Institute of Anesthesia and Intensive Care, University Hospital of Padua, Padua, Italy.

PMID: 42106240
DOI: 10.1016/j.bja.2026.03.062

No abstract available

Keywords: bupivacaine; erector spinae plane block; levobupivacaine; lidocaine; local anaesthetic systemic toxicity; pharmacokinetics; ropivacaine; systemic absorption.

Publication types

Letter