Trans-arterial gemcitabine micro perfusion of locally advanced pancreatic cancer enabled by coil plus glue embolization of a pancreaticoduodenal branch

Bela Kis; Olivia Bishop; Elias Salloum; Mustafa Al-Roubaie; Dae Won Kim; Ramtin Agah

doi:10.1016/j.radcr.2026.04.043

Trans-arterial gemcitabine micro perfusion of locally advanced pancreatic cancer enabled by coil plus glue embolization of a pancreaticoduodenal branch

Radiol Case Rep. 2026 May 7;21(8):3012-3015. doi: 10.1016/j.radcr.2026.04.043. eCollection 2026 Aug.

Authors

Bela Kis¹, Olivia Bishop¹, Elias Salloum¹, Mustafa Al-Roubaie¹, Dae Won Kim², Ramtin Agah³

Affiliations

¹ Diagnostic Imaging and Interventional Radiology, Moffitt Cancer Center, Tampa, FL, United States.
² Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL, United States.
³ RenovoRx, Inc., Los Altos, CA, United States.

Abstract

Trans-arterial micro perfusion (TAMP) is a technique that utilizes a novel double-balloon occlusion catheter (RenovoCath) for localized drug delivery in the absence of tumor feeder vessels. Side branch exclusion is a prerequisite for achieving the intra-arterial pressure that drives TAMP. We report a case in which coil plus glue embolization of a vessel side branch successfully enabled TAMP-mediated drug delivery. An 82-year-old male with locally advanced pancreatic cancer was referred for gemcitabine treatment via TAMP. Angiography identified the superior mesenteric artery (SMA) as the best target; however, a pancreaticoduodenal artery (PDA) branch of the SMA could not be excluded. Complete occlusion of the PDA branch was achieved with coil plus glue embolization; TAMP-mediated gemcitabine delivery was then successfully performed in the same setting. In cases where arterial anatomy may otherwise preclude TAMP, coil plus glue embolization of side branches may provide a viable solution.

Keywords: Arterial embolization; Chemoperfusion; Locally advanced pancreatic cancer; Trans-arterial micro perfusion.

Publication types

Case Reports