Trichostatin Analogues From the Karst Cave Associated Streptomyces sp. DX6D14

Chem Biodivers. 2026 May;23(5):e71334. doi: 10.1002/cbdv.71334.

Abstract

Six new trichostatin analogs, designated karstmycins I-M (1-6), together with eight known congeners (7-14), were obtained from Streptomyces sp. DX6D14 isolated from the soil of the karst cave. The structures of the new compounds were elucidated through spectroscopic analysis, including high-resolution electron spray ionization mass spectrometry (HRESIMS) and nuclear magnetic resonance (NMR), and electronic circular dichroism (ECD) calculations. All the isolates were evaluated for antibacterial and cytotoxic activities.

MeSH terms

  • Anti-Bacterial Agents* / chemistry
  • Anti-Bacterial Agents* / isolation & purification
  • Anti-Bacterial Agents* / pharmacology
  • Antineoplastic Agents* / chemistry
  • Antineoplastic Agents* / isolation & purification
  • Antineoplastic Agents* / pharmacology
  • Caves / microbiology
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Drug Screening Assays, Antitumor
  • Humans
  • Hydroxamic Acids* / chemistry
  • Hydroxamic Acids* / isolation & purification
  • Hydroxamic Acids* / pharmacology
  • Microbial Sensitivity Tests
  • Molecular Conformation
  • Molecular Structure
  • Streptomyces* / chemistry
  • Streptomyces* / metabolism

Substances

  • Hydroxamic Acids
  • Anti-Bacterial Agents
  • Antineoplastic Agents