Do peripheral nerves contain a factor inducing acetylcholine sensitivity in skeletal muscle?

Experientia. 1979 Feb 15;35(2):218-9. doi: 10.1007/BF01920626.

Abstract

A crude extract of the sciatic nerve, eluate of dialyzed nerve extract or 2 folin-positive sephadex fractions induced acetylcholine sensitivity of extrajunctional regions in extensor digitorum longus muscle fibres of the rat, when released from silastic plates implanted for 3--4 days onto the muscle surface.

MeSH terms

  • Acetylcholine / pharmacology*
  • Animals
  • Cell Differentiation
  • Dose-Response Relationship, Drug
  • Female
  • Membrane Potentials / drug effects
  • Motor Endplate / physiology*
  • Neuromuscular Junction / physiology*
  • Neuromuscular Junction / ultrastructure*
  • Peripheral Nerves / physiology*
  • Rats
  • Receptors, Cholinergic / drug effects
  • Sciatic Nerve / physiology

Substances

  • Receptors, Cholinergic
  • Acetylcholine