Effect of aspirin and vitamins C and E on synovial rheumatoid arthritic and other cells

Experientia. 1979 Feb 15;35(2):244-6. doi: 10.1007/BF01920642.

Abstract

Normal and rheumatoid arthritic human synovial cells, normal rat muscle and bone cells, were cultured with combinations of aspirin (acetylsalicytic acid), vitamins C and E. Aspirin reduced percent growth of all cells by about 1/5 relative to controls. High vitamin C eradicated arthritic cells. In combinations, vitamin C was most important in eradicating arthritic cells. A low-vitamin C combination was most effective in reducing arthritic cell populations, while having little effect on normal cells. Vitamin E retarded but did not prevent the action of vitamin C.

MeSH terms

  • Arthritis, Rheumatoid / pathology*
  • Ascorbic Acid / pharmacology*
  • Aspirin / pharmacology*
  • Bone and Bones / cytology
  • Cell Division / drug effects
  • Cell Line
  • Cell Survival / drug effects
  • Dose-Response Relationship, Drug
  • Drug Interactions
  • Humans
  • Muscles / cytology
  • Synovial Fluid / cytology*
  • Vitamin E / pharmacology*

Substances

  • Vitamin E
  • Ascorbic Acid
  • Aspirin