Advances in biomaterials

Int Rev Cell Mol Biol. 2026:402:1-59. doi: 10.1016/bs.ircmb.2025.11.005. Epub 2025 Dec 2.

Abstract

Biomaterials have emerged as a cornerstone of modern medicine, significantly advancing patient care across various clinical applications. This chapter delves into the evolution and classification of biomaterials, highlighting both synthetic and natural types, and elucidating their critical roles in prosthetics, drug delivery systems, and regenerative medicine. The historical context of biomaterials reveals their initial use in ancient practices, evolving into sophisticated materials engineered for enhanced biocompatibility and functionality. With technological advancements, materials such as metals, polymers, and composites have been developed to facilitate seamless integration with biological systems, minimizing complications and improving device durability. Innovative fabrication techniques, including 3D bioprinting, electrospinning, and microfluidic systems, have expanded the potential for creating complex structures that closely mimic natural tissues, revolutionizing tissue engineering and organ replacement strategies. The chapter emphasizes the transformative impact of nanoscale materials in drug delivery and diagnostics, offering targeted therapies, improved imaging methods, and enhanced therapeutic efficacy. Despite considerable progress, challenges remain, including long-term performance, regulatory compliance, and biocompatibility. As the field evolves, interdisciplinary collaboration and ongoing research are vital to overcoming these challenges. This overview aims to inform readers about the latest advancements in biomaterials and their myriad applications, fostering continued innovation in biomedical engineering for improved health outcomes.

Keywords: Bioengineering application; Biomaterials; Natural polymers; Synthetic polymers.

Publication types

  • Review

MeSH terms

  • Animals
  • Biocompatible Materials* / chemistry
  • Drug Delivery Systems
  • Humans
  • Polymers / chemistry
  • Regenerative Medicine
  • Tissue Engineering / methods

Substances

  • Biocompatible Materials
  • Polymers