Update to RIFM fragrance ingredient safety assessment, methyl 3-hydroxyhexanoate, CAS Registry Number 21188-58-9

A M Api; A Bartlett; D Belsito; D Botelho; M Bruze; A Bryant-Friedrich; G A Burton Jr; M A Cancellieri; H Chon; M Cronin; S Crotty; M L Dagli; W Dekant; C Deodhar; K Farrell; A D Fryer; L Jones; K Joshi; A Lapczynski; D L Laskin; M Lavelle; I Lee; H Moustakas; J Muldoon; T M Penning; A H Piersma; G Ritacco; N Sadekar; I Schember; T W Schultz; F Siddiqi; I G Sipes; G Sullivan; Y Thakkar

doi:10.1016/j.fct.2026.116202

Update to RIFM fragrance ingredient safety assessment, methyl 3-hydroxyhexanoate, CAS Registry Number 21188-58-9

Food Chem Toxicol. 2026 Jun 6:216 Suppl 1:116202. doi: 10.1016/j.fct.2026.116202. Online ahead of print.

Authors

A M Api¹, A Bartlett¹, D Belsito², D Botelho¹, M Bruze³, A Bryant-Friedrich⁴, G A Burton Jr⁵, M A Cancellieri¹, H Chon¹, M Cronin⁶, S Crotty¹, M L Dagli⁷, W Dekant⁸, C Deodhar¹, K Farrell¹, A D Fryer⁹, L Jones¹, K Joshi¹, A Lapczynski¹, D L Laskin¹⁰, M Lavelle¹, I Lee¹, H Moustakas¹, J Muldoon¹, T M Penning¹¹, A H Piersma¹², G Ritacco¹, N Sadekar¹, I Schember¹, T W Schultz¹¹, F Siddiqi¹, I G Sipes¹³, G Sullivan¹⁴, Y Thakkar¹

Affiliations

¹ Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.
² Member Expert Panel for Fragrance Safety, Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Ave., New York, NY, 10032, USA.
³ Member Expert Panel for Fragrance Safety, Malmo University Hospital, Department of Occupational & Environmental Dermatology, Sodra Forstadsgatan 101, Entrance 47, Malmo, SE-20502, Sweden.
⁴ Member Expert Panel for Fragrance Safety, Pharmaceutical Sciences, Wayne State University, 42 W. Warren Ave., Detroit, MI, 48202, USA.
⁵ Member Expert Panel for Fragrance Safety, School of Natural Resources & Environment, University of Michigan, Dana Building G110, 440 Church St., Ann Arbor, MI, 58109, USA.
⁶ Member Expert Panel for Fragrance Safety, Liverpool John Moores University, School of Pharmacy and Biomolecular Sciences, Liverpool, United Kingdom.
⁷ Member Expert Panel for Fragrance Safety, University of Sao Paulo, School of Veterinary Medicine and Animal Science, Department of Pathology, Av. Prof. dr. Orlando Marques de Paiva, 87, Sao Paulo, CEP 05508-900, Brazil.
⁸ Member Expert Panel for Fragrance Safety, University of Wuerzburg, Department of Toxicology, Versbacher Str. 9, Würzburg, 97078, Germany.
⁹ Member Expert Panel for Fragrance Safety, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, OR, 97239, USA.
¹⁰ Member Expert Panel for Fragrance Safety, Rutgers University Ernest Mario School of Pharmacy, Distinguished Professor and Chair, Department of Pharmacology and Toxicology, 160 Frelinghuysen Road, Piscataway, NJ, 08854, USA.
¹¹ Member Expert Panel for Fragrance Safety, University of Pennsylvania, Perelman School of Medicine, Center of Excellence in Environmental Toxicology, 1316 Biomedical Research Building (BRB) II/III, 421 Curie Boulevard, Philadelphia, PA, 19104-3083, USA.
¹² Member Expert Panel for Fragrance Safety, Utrecht University, Institute for Risk Assessment Sciences (IRAS), Netherlands.
¹³ Member Expert Panel for Fragrance Safety, Department of Pharmacology, University of Arizona, College of Medicine, 1501 North Campbell Avenue, P.O. Box 245050, Tucson, AZ, 85724-5050, USA.
¹⁴ Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA. Electronic address: gsullivan@rifm.org.

PMID: 42252020
DOI: 10.1016/j.fct.2026.116202

No abstract available