Charting human cellular senescence in aging and disease

Vidyani Suryadevara; Negin Farzad; Mingyu Yang; Ke Xu; Alexander Tsankov; Ryan C Thompson; Nick Sloan; Hemali Phatnani; Bradley Olinger; Jason A Mares; Anina N Lund; Dongmei Li; Myriam Gorospe; Li Ding; Noam Beckmann; Nathan Basisty; Carlos Anerillas; NIH SenNet consortium; Paul Robbins; Rong Fan

doi:10.1016/j.cell.2026.05.028

Charting human cellular senescence in aging and disease

Cell. 2026 Jun 11;189(12):3501-3505. doi: 10.1016/j.cell.2026.05.028.

Authors

Vidyani Suryadevara¹, Negin Farzad², Mingyu Yang², Ke Xu³, Alexander Tsankov³, Ryan C Thompson⁴, Nick Sloan⁵, Hemali Phatnani⁵, Bradley Olinger⁶, Jason A Mares⁷, Anina N Lund⁴, Dongmei Li⁸, Myriam Gorospe⁹, Li Ding¹⁰, Noam Beckmann⁴, Nathan Basisty⁶, Carlos Anerillas¹¹; NIH SenNet consortium; Paul Robbins¹², Rong Fan¹³

Affiliations

¹ Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: vidyani@stanford.edu.
² Yale Center for Research on Aging, Yale School of Medicine, New Haven, CT, USA.
³ Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY, USA.
⁴ Windreich Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.
⁵ Department of Neurology, Columbia Irving Medical Center, New York, NY, USA; New York Genome Center, New York, NY, USA.
⁶ Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, USA.
⁷ Department of Neurology, Columbia Irving Medical Center, New York, NY, USA.
⁸ Clinical and Translational Science Institute, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY, USA.
⁹ Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD, USA.
¹⁰ Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA.
¹¹ Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, USA; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA; Tissue and Organ Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain; Instituto Aragones de Ciencias de la Salud (IACS) and Fundación Agencia Aragonesa para la Investigación y el Desarrollo (ARAID), Zaragoza, Spain.
¹² Department of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, MN, USA.
¹³ Yale Center for Research on Aging, Yale School of Medicine, New Haven, CT, USA. Electronic address: rong.fan@yale.edu.

PMID: 42276030
DOI: 10.1016/j.cell.2026.05.028

Abstract

Cellular senescence comprises diverse cell states emerging across human tissues during aging and disease. Integrating single-cell and spatial multi-omics with AI-driven analyses enables systematic mapping of senescent cell heterogeneity ("senotypes"), revealing tissue-specific programs and microenvironmental interactions. These advances provide frameworks for biomarker discovery and development of targeted senotherapeutic strategies.

Publication types

Review

MeSH terms

Aging*
Biomarkers / metabolism
Cellular Senescence*
Humans
Multiomics

Substances

Biomarkers