Cancer of the pancreas in Olmsted County, Minnesota, 1935-1974

Mayo Clin Proc. 1979 Apr;54(4):245-9.

Abstract

All confirmed cases of pancreatic carcinoma in bona fida residents of Olmsted County, Minnesota, from 1935 through 1974 were identified and reviewed. The average annual age-adjusted incidence rates were 7.4 for males and 3.5 for females per 100,000 population. Rates increased with age for both sexes and increased slightly over the 40-year period of study, with lower incidence rates observed for rural inhabitants in the first 2 decades. At the time of diagnosis, almost 75% of patients were 60 years of age or older and adenocarcinoma was histologically identified in 92% of the cases. One-year survival was 11%, and all patients died within 3 years of the initial diagnosis. An association between pancreatic carcinoma and diabetes was noted. There does not appear to be a clear association with cholelithiasis or chronic pancreatitis. There was a high percentage (20%) of multiple primary carcinomas and an overrepresentation of metal workers observed among patients with pancreatic carcinoma.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenocarcinoma / epidemiology*
  • Adenocarcinoma / mortality
  • Adult
  • Age Factors
  • Aged
  • Alcoholism / complications
  • Cholelithiasis / complications
  • Diabetes Complications
  • Environmental Pollutants / adverse effects
  • Female
  • Humans
  • Male
  • Middle Aged
  • Minnesota
  • Neoplasms, Multiple Primary / epidemiology
  • Pancreatic Neoplasms / epidemiology*
  • Pancreatic Neoplasms / mortality
  • Pancreatitis / complications
  • Rural Population
  • Sex Factors
  • Urban Population

Substances

  • Environmental Pollutants