Curcumin and Cognitive Health: Insights from Randomized Controlled Trials

Abstract

Curcumin has garnered attention for its potential neuroprotective effects, attributed to its antioxidant and anti-inflammatory properties. This review summarizes the results of Randomized Controlled Trials (RCTs) evaluating the impact of curcumin supplementation on cognitive function in adults. Several studies have reported that curcumin supplementation could improve cognitive domains, including memory, attention, and processing speed. Nano-formulations of curcumin provide better bioavailability and improved bioactivities. Curcumin supplementation (Longvida®, Theracurmin®, and CurQfen®) has shown significant benefits for cognitive function in humans. Studies have reported improvements in working memory, attention, mood, and cerebral blood flow, particularly in older adults. Some trials also demonstrate reductions in neuroinflammatory markers and amyloid/tau deposition. However, results across studies are heterogeneous, potentially due to variations in curcumin formulations, dosages, study durations, and participant characteristics. In conclusion, curcumin shows promise as a cognitive enhancer in humans. However, further large-scale, standardized RCTs are necessary to establish optimal dosing strategies and confirm their efficacy across diverse populations.

Keywords: Curcuma longa; Curcumin; cognition; memory; nano-curcumin; neuroprotection.