Sealing and healing: A two-step model for plasma membrane repair

Athanasios Kournoutis; Harald Stenmark

doi:10.1016/j.devcel.2026.06.011

Sealing and healing: A two-step model for plasma membrane repair

Dev Cell. 2026 Jul 8;61(7):1345-1346. doi: 10.1016/j.devcel.2026.06.011.

Authors

Athanasios Kournoutis¹, Harald Stenmark²

Affiliations

¹ Centre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, Montebello, 0379 Oslo, Norway; Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, 0379 Oslo, Norway.
² Centre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, Montebello, 0379 Oslo, Norway; Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, 0379 Oslo, Norway. Electronic address: stenmark@ulrik.uio.no.

PMID: 42419281
DOI: 10.1016/j.devcel.2026.06.011

Abstract

Plasma membrane damage can cause cell death and is associated with neurodegeneration. In this issue of Developmental Cell, Heffner et al. show that annexin A11 (ANXA11) first plugs membrane lesions, before ESCRT-III is recruited to extrude the damaged patch-a two-step repair mechanism compromised by ALS- and FTD-linked mutations.

Publication types

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MeSH terms

Animals
Annexins* / metabolism
Cell Membrane* / metabolism
Endosomal Sorting Complexes Required for Transport / metabolism
Humans
Models, Biological
Mutation

Substances

Annexins
Endosomal Sorting Complexes Required for Transport