The PRECISE European initiative for cancer-vulnerability mapping and prediction
Nat Genet
.
2026 Aug;58(8):1738-1744.
doi: 10.1038/s41588-026-02658-z.
Authors
Francesco Iorio
#
1
,
Mathew J Garnett
#
2
,
Pedro Beltrao
3
,
Maximilian Billmann
4
,
Larissa Bless
5
,
Christoph Bock
6
7
,
Michael Boutros
8
,
Alejandra Bruna
9
10
,
Piero Carninci
11
12
,
Giovanni Ciriello
13
,
Isidro Cortés-Ciriano
14
15
,
Giuseppina D'Alessandro
16
,
Roberta Esposito
17
18
,
Stefania Faletti
11
,
Emanuel Gonçalves
19
20
,
Syed Haider
21
,
Nereo Kalebic
11
,
Manuel Kaulich
22
23
,
Giuseppe Leuzzi
16
,
Nuria Lopez-Bigas
24
25
26
,
Christopher J Lord
21
,
Evangelia Petsalaki
15
27
,
Stephen Pettitt
21
,
Ludovica Proietti
11
,
Roland Rad
28
29
,
Nevenka Radic
11
,
Colm J Ryan
30
31
,
Jonathan L Schmid-Burgk
32
,
Sumana Sharma
33
,
Andrea Sottoriva
11
,
Christopher Tape
34
,
Livio Trusolino
35
36
,
Jolanda van Leeuwen
37
38
,
David Walter
39
,
Lodewyk Wessels
40
41
;
PRECISE consortium
Affiliations
1
Human Technopole, Milan, Italy. francesco.iorio@fht.org.
2
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK. mg12@sanger.ac.uk.
3
Institute of Molecular Systems Biology, ETH Zürich, Zurich, Switzerland.
4
Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany.
5
Dublin City University, Dublin, Ireland.
6
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
7
Medical University of Vienna, Institute of Artificial Intelligence, Center for Medical Data Science, Vienna, Austria.
8
Institute of Human Genetics and German Cancer Research Center (DKFZ), Heidelberg University, Heidelberg, Germany.
9
Centre for Evolution and Cancer, Division of Cancer Biology, The Institute of Cancer Research, Sutton, UK.
10
Centre for Children and Young People's Cancer, The Institute of Cancer Research, Sutton, UK.
11
Human Technopole, Milan, Italy.
12
RIKEN Center for Integrative Medical Sciences, Yokohama City, Japan.
13
Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
14
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
15
European Molecular Biology Laboratory-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, UK.
16
IFOM ETS-The AIRC Institute of Molecular Oncology, Milan, Italy.
17
Urology Research Laboratory, Department for BioMedical Research, University of Bern, Bern, Switzerland.
18
Department of Urology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
19
Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.
20
INESC-ID, Lisboa, Portugal.
21
The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
22
Institute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt, Germany.
23
Frankfurt Cancer Institute, Frankfurt, Germany.
24
Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.
25
Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain.
26
Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain.
27
Oncology Data Science, GSK, Stevenage, UK.
28
Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technical University of Munich, Munich, Germany.
29
German Cancer Consortium, German Cancer Research Center (DKFZ) Heidelberg, Heidelberg, Germany.
30
Conway Institute, University College Dublin, Dublin, Ireland.
31
School of Medicine, University College Dublin, Dublin, Ireland.
32
Institute of Clinical Chemistry and Clinical Pharmacology, University and University Hospital Bonn, Bonn, Germany.
33
Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
34
Cancer Institute, University College London, London, UK.
35
Candiolo Cancer Institute FPO IRCCS, Candiolo, Torino, Italy.
36
Department of Oncology, University of Torino, Candiolo, Torino, Italy.
37
Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
38
Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
39
Cancer Research Horizons, Cambridge, UK.
40
The Netherlands Cancer Institute, Amsterdam, the Netherlands.
41
The Oncode Institute, Utrecht, the Netherlands.
#
Contributed equally.
PMID:
42432245
DOI:
10.1038/s41588-026-02658-z
No abstract available