Characterisation of the Novel HLA-DPB1*04:01:116 Allele by Sequencing-Based Typing

HLA. 2026 Jul;108(1):e70855. doi: 10.1111/tan.70855.

Abstract

HLA-DPB1*04:01:116 differs from HLA-DPB1*04:01:01:01 by one nucleotide substitution in codon 43 in exon 2.

Keywords: HLA‐DPB1*04:01:116; HLA; bone marrow donor; novel allele; sequencing‐based typing.

MeSH terms

  • Alleles*
  • Base Sequence
  • Codon / chemistry
  • Exons*
  • HLA-DP beta-Chains* / genetics
  • HLA-DP beta-Chains* / immunology
  • Histocompatibility Testing
  • Humans
  • Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide*
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Tissue Donors

Substances

  • HLA-DP beta-Chains
  • Codon
  • HLA-DPB1 antigen