Increased release of tumour cells by collagenase at acid pH: a possible mechanism for metastasis

Experientia. 1979 Dec 15;35(12):1657-8. doi: 10.1007/BF01953252.


The ability of collagenase to disaggregate a solid metastasizing lymphosarcoma has been shown to considerably increase with reducing environmental pH. It is suggested that this effect may be operating in vivo to release cells from a primary tumour.

MeSH terms

  • Animals
  • Cricetinae
  • Hydrogen-Ion Concentration
  • Lymphoma, Non-Hodgkin / physiopathology*
  • Mesocricetus
  • Microbial Collagenase*
  • Neoplasm Metastasis*
  • Neoplasms, Experimental / physiopathology


  • Microbial Collagenase