Abstract
The effect of ribonucleosides and deoxyribonucleosides on the phosphorolysis of 5-fluoro-2'-deoxyuridine (FUdR) was examined in cells of Escherichia coli. All nucleosides tested except guanosine and deoxyguanosine inhibited phosphorolysis. By using genetically marked strains it was found that in vivo FUdR is a specific substrate of thymidine phosphorylase.
MeSH terms
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Culture Media
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Deoxyribonucleosides / pharmacology
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Escherichia coli / enzymology
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Escherichia coli / growth & development
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Escherichia coli / metabolism*
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Floxuridine / metabolism*
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Nucleosides / pharmacology*
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Pentosyltransferases / antagonists & inhibitors
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Pentosyltransferases / metabolism
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Ribonucleosides / pharmacology
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Thymidine / metabolism
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Tritium
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Uridine / metabolism
Substances
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Culture Media
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Deoxyribonucleosides
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Nucleosides
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Ribonucleosides
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Floxuridine
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Tritium
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Pentosyltransferases
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Thymidine
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Uridine