Mediastinal lymph node biopsy in sarcoidosis

Endoscopy. 1979 Feb;11(1):5-8. doi: 10.1055/s-0028-1098315.


Mediastinoscopy, in the skilled hands of a thoracic surgeon has proved to be a safe, cosmetically accepted procedure with negligible complications. It has yielded a high rate of diagnostic lymph node tissue; overall greater than 82% among patients with sarcoidosis, including patients presenting with pulmonary mottling only or with a normal chest radiograph. Among patients with lymphatic tuberculosis it enabled the isolation of human M. tuberculosis following culture of the lymph node removed on Löwenstein-Jensen medium in greater than 79% of cases. A precise histological diagnosis was obtained in all 14 patients presenting with hilar and/or paratracheal lymphadenopathy attributable to malignant disease.

MeSH terms

  • Adult
  • Biopsy
  • Female
  • Humans
  • Kveim Test
  • Lymph Nodes / pathology*
  • Mediastinoscopy*
  • Radiography
  • Sarcoidosis / diagnosis*
  • Sarcoidosis / diagnostic imaging
  • Sarcoidosis / pathology
  • Tuberculosis, Lymph Node / diagnosis