Human growth hormone release: relation to slow-wave sleep and sleep-walking cycles

Science. 1969 Aug 1;165(3892):513-5. doi: 10.1126/science.165.3892.513.


Release of human growth hormone during sleep is significantly related to slow, synchronized stages of sleep and therefore would seem to be controlled by related neural mechanisms. When sleep-waking cycles are reversed by 12 hours, the release of growth hormone with sleep is reversed; thus release does not follow an inherent circadian rhythm independent of sleep.

MeSH terms

  • Adult
  • Electroencephalography
  • Electromyography
  • Growth Hormone / blood*
  • Heart Rate
  • Humans
  • Male
  • Periodicity*
  • Sleep Stages
  • Sleep*
  • Sleep, REM


  • Growth Hormone