"Activation" of vitamin D by the liver

J Clin Invest. 1969 Nov;48(11):2032-7. doi: 10.1172/JCI106168.


Isolation of the liver from the circulation of rats eliminates almost completely their ability to convert [1,2]-(3)H vitamin D(3) into its biologically active metabolite, 25-hydroxycholecalciferol, as well as certain other metabolites. It is concluded that the liver is the major if not the only physiologic site of hydroxylation of vitamin D(3) (cholecalciferol) into 25-hydroxycholecalciferol. The osteodystrophy and the higher requirements for vitamin D observed in hepatic insufficiencies may be due to an inability of the liver to transform vitamin D into its metabolically active form.

MeSH terms

  • Animals
  • Cholecalciferol / blood
  • Cholecalciferol / metabolism*
  • Chromatography
  • Hepatectomy
  • Liver / metabolism*
  • Liver Diseases / complications
  • Male
  • Osteomalacia / etiology
  • Osteoporosis / etiology
  • Rats
  • Rickets / etiology
  • Tritium
  • Vitamin D / metabolism


  • Tritium
  • Vitamin D
  • Cholecalciferol