The actions of 5-hydroxytryptamine and histamine on the isolated ileum of the tree shrew (Tupaia glis)

Br J Pharmacol. 1979 Jul;66(3):405-8. doi: 10.1111/j.1476-5381.1979.tb10845.x.


1. Contractions to 5-hydroxytryptamine (5-HT) and histamine of longitudinal muscle from the isolated ileum of the tree shrew (Tupaia), guinea-pig and rat were investigated by constructing dose-response curves and studying the effects of various antagonists. 2 In the Tupaia and rat ileum the contraction to 5-HT was reduced by methysergide but not affected by tetrodotoxin (TTX), morphine, hexamethonium (C6) or atropine. The response of guinea-pig ileum to 5-HT was not significantly inhibited by methysergide or C6, but was blocked by TTX, morphine and atropine. 3 Histamine-induced contraction of Tupaia and guinea-pig ileum was antagonized by diphenhydramine but not by TTX, morphine, C6 or atropine. Histamine was almost without effect on the rat ileum.

MeSH terms

  • Animals
  • Guinea Pigs
  • Histamine / pharmacology*
  • Histamine H1 Antagonists / pharmacology
  • Ileum / drug effects
  • In Vitro Techniques
  • Male
  • Muscle Contraction / drug effects*
  • Muscle, Smooth / drug effects*
  • Rats
  • Serotonin / pharmacology*
  • Species Specificity
  • Strepsirhini / physiology*
  • Tupaiidae / physiology*


  • Histamine H1 Antagonists
  • Serotonin
  • Histamine