Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1971 May;215(1):269-82.
doi: 10.1113/jphysiol.1971.sp009468.

The Effect of Angiotensin on Cation Transport by Rat Kidney Cortex Slices

Free PMC article

The Effect of Angiotensin on Cation Transport by Rat Kidney Cortex Slices

K A Munday et al. J Physiol. .
Free PMC article

Abstract

1. A study has been made of the effect of angiotensin (10(-12) g/ml.) on active and passive transport of sodium, potassium and water between rat kidney cortex slices and the incubation medium.2. Angiotensin has no effect on the passive uptake of sodium and loss of potassium by slices incubated under conditions which inhibit active transport.3. Active sodium extrusion by slices incubated under aerobic conditions is stimulated, whereas active potassium uptake is inhibited by angiotensin.4. Sodium pump activity is stimulated by angiotensin in the presence of ouabain or in the absence of potassium in the incubation medium, conditions which block the sodium for potassium exchange pump.5. There is a 2 min latent period following the application of angiotensin before a response is observed.6. These findings are discussed in relation to the mechanism of action of angiotensin on kidney sodium and fluid transport processes.

Similar articles

See all similar articles

Cited by 12 articles

See all "Cited by" articles

References

    1. Physiol Rev. 1967 Jul;47(3):359-82 - PubMed
    1. Recent Prog Horm Res. 1966;22:381-430 - PubMed
    1. Biochem J. 1965 Oct;97(1):214-27 - PubMed
    1. J Gen Physiol. 1966 Jul;49(6):1221-39 - PubMed
    1. J Physiol. 1967 Sep;192(2):36P-38P - PubMed

LinkOut - more resources

Feedback