Synthesis of 5-fluorouridine 5'-phosphate by a pyrimidine phosphoribosyltransferase of mammalian origin. II. Correlation between the tumor levels of the enzyme and the 5-fluorouracil-promoted increase in survival of tumor-bearing mice

Biochem Pharmacol. 1969 Oct;18(10):2587-90. doi: 10.1016/0006-2952(69)90378-5.
No abstract available

MeSH terms

  • Animals
  • Fluorouracil / metabolism*
  • Fluorouracil / therapeutic use*
  • Leukemia L1210 / drug therapy
  • Leukemia L1210 / enzymology
  • Lymphoma / drug therapy
  • Lymphoma / enzymology
  • Mice
  • Neoplasm Transplantation
  • Neoplasms, Experimental / drug therapy*
  • Neoplasms, Experimental / enzymology*
  • Pentosephosphates
  • Phosphoric Acids
  • Ribose
  • Transferases*
  • Uracil Nucleotides / biosynthesis*

Substances

  • Pentosephosphates
  • Phosphoric Acids
  • Uracil Nucleotides
  • Ribose
  • Transferases
  • Fluorouracil