Trisodium phosphonoformate inhibits hepatitis B Dane particle DNA polymerase

Acta Pathol Microbiol Scand B. 1979 Feb;87B(1):75-6. doi: 10.1111/j.1699-0463.1979.tb02406.x.


Evidence available indicates that the so-called Dane particles are the hepatitis virus. A DNA polymerase is associated with the core of these particles. The probability that this is the viral DNA polymerase offers the possibility of preventing hepatitis B multiplication by selective inhibition of this enzyme. This investigation reports that trisodium phosphonoformate (PFA) at low concentrations but not phosphonoacetate acid (PAA) inhitits Dane particle associated DNA polymerase.

MeSH terms

  • Formates / pharmacology*
  • Hepatitis B Antigens*
  • Nucleic Acid Synthesis Inhibitors*


  • Formates
  • Hepatitis B Antigens
  • Nucleic Acid Synthesis Inhibitors