Treatment of Goodpasture's syndrome with plasmapheresis. A case report and review of the literature

Am J Med. 1979 Apr;66(4):689-96. doi: 10.1016/0002-9343(79)91186-0.


A case is reported of antiglomerular basement membrane antibody-induced Goodpasture's syndrome in which the patient required hemodialysis and was treated with immunosuppressive agents and plasmapheresis. A severe (80 per cent) cresentic lesion was reversed, and creatinine was stabilized at 2.5 mg/dl at one year follow-up. Earlier reports of therapy without plasmapheresis showed that 88 per cent of the patients would either die or require long-term hemodialysis. Fifteen other reported cases of Goodpasture's syndrome in which the patients were treated with plasmapheresis are reviewed. When reported, short-term follow-up showed that nine of these patients were alive without need of dialysis, five wee receiving dialysis, and only two had died. This suggests that plasmaheresis and immunosuppressive therapy may reverse the renal lesion in some patients with Goodpasture's syndrome.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Anti-Glomerular Basement Membrane Disease / pathology*
  • Anti-Glomerular Basement Membrane Disease / therapy*
  • Cyclophosphamide / therapeutic use
  • Follow-Up Studies
  • Humans
  • Kidney / pathology
  • Male
  • Plasmapheresis*
  • Prednisone / therapeutic use
  • Renal Dialysis


  • Cyclophosphamide
  • Prednisone