Cerium nitrate-silver sulfadiazine cream in the treatment of burns: a prospective, randomized study

Am Surg. 1979 Apr;45(4):270-2.


In a prospective, randomized study of 34 patients with thermal burns, treatment with the topical agent Cerium nitrate-silver sulfadiazine was compared with therapy with silver sulfadiazine alone. Despite randomization, there was a significant difference in mean burn size, being larger in the silver sulfadiazine group. There was no significant difference between the two groups in clinical course, mortality, septic deaths, or quantitative microbiology of the burn wound. It is concluded that from these preliminary data no clearcut superiority for one cream over the other can be demonstrated at this time.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Bacteria / isolation & purification
  • Burns / drug therapy*
  • Burns / microbiology
  • Cerium / therapeutic use*
  • Drug Combinations
  • Female
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Nitrates / therapeutic use*
  • Prospective Studies
  • Silver Sulfadiazine / therapeutic use*
  • Sulfadiazine / therapeutic use*
  • Wound Infection / drug therapy
  • Wound Infection / microbiology


  • Drug Combinations
  • Nitrates
  • Sulfadiazine
  • Cerium
  • Silver Sulfadiazine