Antiviral effects of aphidicolin, a new antibiotic produced by Cephalosporium aphidicola

Antimicrob Agents Chemother. 1973 Sep;4(3):294-8. doi: 10.1128/aac.4.3.294.

Abstract

Aphidicolin is an antibiotic of novel structure produced by the mold Cephalosporium aphidicola. It is a potent inhibitor of cellular deoxyribonucleic acid synthesis, and it also strongly inhibits the growth of herpes simplex virus both in tissue culture and in the rabbit eye. Aphidicolin is active against iododeoxyuridine-resistant herpes virus, and does not itself readily induce the formation of drug-resistant strains of herpesvirus.

MeSH terms

  • Acremonium / metabolism*
  • Animals
  • Anti-Bacterial Agents / pharmacology*
  • Anti-Bacterial Agents / therapeutic use
  • Antiviral Agents / pharmacology*
  • Antiviral Agents / therapeutic use
  • Cattle
  • Cell Line
  • Cornea
  • Culture Techniques
  • Cytarabine / pharmacology
  • DNA, Viral / biosynthesis
  • Diterpenes / pharmacology*
  • Diterpenes / therapeutic use
  • Drug Resistance, Microbial
  • Embryo, Mammalian
  • Humans
  • Idoxuridine / pharmacology
  • Keratitis, Dendritic / drug therapy
  • Kidney
  • Lung
  • Microbial Sensitivity Tests
  • Rabbits
  • Simplexvirus / drug effects

Substances

  • Anti-Bacterial Agents
  • Antiviral Agents
  • DNA, Viral
  • Diterpenes
  • Cytarabine
  • Idoxuridine