Human antigen and enzyme markers in man-Chinese hamster somatic cell hybrids: evidence for synteny between the HL-A, PGM3, ME1, and IPO-B loci

H van Someren; A Westerveld; A Hagemeijer; J R Mees; P Meera Khan; O B Zaalberg

doi:10.1073/pnas.71.3.962

Human antigen and enzyme markers in man-Chinese hamster somatic cell hybrids: evidence for synteny between the HL-A, PGM3, ME1, and IPO-B loci

Proc Natl Acad Sci U S A. 1974 Mar;71(3):962-5. doi: 10.1073/pnas.71.3.962.

Authors

H van Someren, A Westerveld, A Hagemeijer, J R Mees, P Meera Khan, O B Zaalberg

Abstract

In man-Chinese hamster somatic cell hybrids the segregation of the loci for 27 human enzyme markers and the species-specific surface antigens, including the HL-A histocompatibility antigens, was studied. The results show a synteny of the human loci for phosphoglucomutase 3, cytoplasmic malic enzyme, tetrameric indophenol oxidase, and HL-A. Furthermore, evidence is presented that the loci for the human species-specific antigens are distributed over several chromosomes.

MeSH terms

Animals
Antigens / analysis*
Cell Line
Chromosome Mapping*
Cricetinae
Cytotoxicity Tests, Immunologic
Electron Transport Complex IV / biosynthesis*
Fibroblasts
Genes
Genetic Linkage*
HeLa Cells / immunology
Histocompatibility Antigens
Humans
Hybrid Cells / enzymology*
Immune Adherence Reaction
Leukocytes
Malate Dehydrogenase / biosynthesis*
Phosphoglucomutase / biosynthesis*
Skin
Species Specificity

Substances

Antigens
Histocompatibility Antigens
Malate Dehydrogenase
Electron Transport Complex IV
Phosphoglucomutase