Abstract
The production of cytoplasmic RNA that contains polyadenylic acid is increased, relative to total cytoplasmic RNA, in a neuroblastoma clone, NBE-(A), after induction of differentiation by 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone, an inhibitor of adenosine 3',5'-monophosphate phosphodiesterase. The amount of RNA that contains polyadenylic acid in cytoplasm may be greater in such differentiated neuroblastoma cells than in proliferating control cells.
MeSH terms
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Acetyltransferases / metabolism
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Adenosine / metabolism
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Adenosine Monophosphate / biosynthesis
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Adenosine Monophosphate / metabolism*
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Animals
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Benzyl Compounds / pharmacology
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Brain / cytology
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Cell Differentiation / drug effects
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Chickens
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Choline
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Clone Cells / metabolism
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Culture Media
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Cyclic AMP
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Cytoplasm / metabolism
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Ethers / pharmacology
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Imidazoles / pharmacology
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Microscopy, Phase-Contrast
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Neuroblastoma / metabolism*
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Neuroblastoma / pathology
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Phosphodiesterase Inhibitors
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Polynucleotides / metabolism*
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RNA, Neoplasm / biosynthesis
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RNA, Neoplasm / metabolism*
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RNA, Ribosomal / metabolism
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Tritium
Substances
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Benzyl Compounds
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Culture Media
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Ethers
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Imidazoles
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Phosphodiesterase Inhibitors
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Polynucleotides
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RNA, Neoplasm
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RNA, Ribosomal
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Tritium
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Adenosine Monophosphate
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Cyclic AMP
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Acetyltransferases
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Adenosine
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Choline