N-(phosphonacetyl)-L-aspartate, a potent transition state analog inhibitor of aspartate transcarbamylase, blocks proliferation of mammalian cells in culture

J Biol Chem. 1974 Nov 10;249(21):6945-50.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Aspartate Carbamoyltransferase / antagonists & inhibitors*
  • Aspartic Acid / analogs & derivatives*
  • Aspartic Acid / pharmacology
  • Bicarbonates
  • Carbamates
  • Carbon Radioisotopes
  • Cell Division / drug effects*
  • Cell Line
  • Cell Transformation, Neoplastic
  • Cells, Cultured
  • Chromatography, Ion Exchange
  • Fibroblasts
  • Haplorhini
  • Kidney
  • Kinetics
  • Mice
  • Mice, Inbred Strains
  • Organophosphonates / pharmacology*
  • Organophosphorus Compounds
  • Phosphonoacetic Acid / analogs & derivatives
  • Simian virus 40
  • Species Specificity
  • Time Factors
  • Tritium
  • Uridine / pharmacology

Substances

  • Bicarbonates
  • Carbamates
  • Carbon Radioisotopes
  • Organophosphonates
  • Organophosphorus Compounds
  • Tritium
  • Aspartic Acid
  • sparfosic acid
  • Aspartate Carbamoyltransferase
  • Phosphonoacetic Acid
  • Uridine