Abstract
Incubation of liver explants from second-trimester human foetuses with dexamethasone, glucagon or dibutyryl cyclic AMP (plus theophylline) increased the activity of liver cystathionase from unmeasurable or trace values to adult values. Simultaneous incubation with cycloheximide or actinomycin D inhibited this effect.
MeSH terms
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Bucladesine / pharmacology
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Cycloheximide / pharmacology
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Cystathionine gamma-Lyase / biosynthesis*
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Dactinomycin / pharmacology
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Dexamethasone / pharmacology
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Enzyme Induction
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Gestational Age
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Glucagon / pharmacology
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Humans
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Liver / drug effects
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Liver / embryology
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Liver / enzymology*
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Lyases / biosynthesis*
Substances
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Dactinomycin
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Bucladesine
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Dexamethasone
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Glucagon
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Cycloheximide
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Lyases
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Cystathionine gamma-Lyase