Abstract
The minimal inhibitory concentration and the 50% mouse protective dose for five key penicillins are presented. Such data provide a useful guide in evaluating the activity of new penicillins, in comparison with those already commercially available, and establishes the amounts of antibiotic necessary to obtain a PD(50) for several experimental model infections in mice.
MeSH terms
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Ampicillin / pharmacology*
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Animals
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Cloxacillin / pharmacology*
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Dicloxacillin / pharmacology
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Escherichia coli / drug effects
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Escherichia coli Infections / drug therapy
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Methicillin / pharmacology*
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Mice
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Oxacillin / pharmacology*
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Penicillin G / pharmacology*
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Penicillins / therapeutic use*
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Proteus / drug effects
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Proteus Infections / drug therapy
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Salmonella Infections, Animal / drug therapy
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Salmonella paratyphi A / drug effects
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Staphylococcal Infections / drug therapy
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Staphylococcus / drug effects
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Streptococcal Infections / drug therapy
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Streptococcus pneumoniae / drug effects
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Streptococcus pyogenes / drug effects
Substances
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Penicillins
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Ampicillin
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Dicloxacillin
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Cloxacillin
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Penicillin G
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Methicillin
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Oxacillin