Activity of selected penicillins in vitro and in experimental bacterial infections in mice

Appl Microbiol. 1967 May;15(3):566-8. doi: 10.1128/am.15.3.566-568.1967.

Abstract

The minimal inhibitory concentration and the 50% mouse protective dose for five key penicillins are presented. Such data provide a useful guide in evaluating the activity of new penicillins, in comparison with those already commercially available, and establishes the amounts of antibiotic necessary to obtain a PD(50) for several experimental model infections in mice.

Publication types

  • Comparative Study

MeSH terms

  • Ampicillin / pharmacology*
  • Animals
  • Cloxacillin / pharmacology*
  • Dicloxacillin / pharmacology
  • Escherichia coli / drug effects
  • Escherichia coli Infections / drug therapy
  • Methicillin / pharmacology*
  • Mice
  • Oxacillin / pharmacology*
  • Penicillin G / pharmacology*
  • Penicillins / therapeutic use*
  • Proteus / drug effects
  • Proteus Infections / drug therapy
  • Salmonella Infections, Animal / drug therapy
  • Salmonella paratyphi A / drug effects
  • Staphylococcal Infections / drug therapy
  • Staphylococcus / drug effects
  • Streptococcal Infections / drug therapy
  • Streptococcus pneumoniae / drug effects
  • Streptococcus pyogenes / drug effects

Substances

  • Penicillins
  • Ampicillin
  • Dicloxacillin
  • Cloxacillin
  • Penicillin G
  • Methicillin
  • Oxacillin