Genital organs. Auto and homotransplantation in forty dogs

Int J Fertil. 1975;20(1):5-12.

Abstract

Auto and homo transplantation of the uterus and ovaries was studied in 40 bitches divided into four groups. Group A served as a control. In group B the omentopexy technique of auto-transplantation was used. This method did not prove very rewarding and all 12 grafts were found to have degenerated and were non-functioning when relaparotomy was performed, 3 months after transplantation. In group C, auto transplantation with vascular anastomosis was performed in 12 dogs, yielding satisfactory results including one successful pregnancy and the delivery of 3 healthy puppies. In group D homotransplantation of the internal genital organs was performed in two sets of twin dogs. No immunosuppressive treatment was used. These grafts survived for a limited period as proved by the functional tests and X-ray examination but after 3 months were found to be necrotic and degenerated. Graft function and viability was established by: X-ray examination, cytology of vaginal smears, the effect of gonadotropins on the grafted ovaries and finally relaparotomy undertaken after 3 weeks and 3 months.

MeSH terms

  • Animals
  • Chorionic Gonadotropin / pharmacology
  • Dogs
  • Female
  • Gonadotropins, Equine / pharmacology
  • Hysterosalpingography
  • Iliac Artery / surgery
  • Iliac Vein / surgery
  • Ovary / drug effects
  • Ovary / transplantation*
  • Pregnancy
  • Transplantation, Autologous
  • Transplantation, Homologous
  • Uterus / blood supply
  • Uterus / transplantation*
  • Vagina / blood supply
  • Vaginal Smears

Substances

  • Chorionic Gonadotropin
  • Gonadotropins, Equine