Drinking and antidiuresis elicited by isoprenaline in the dog

J Physiol. 1974 Jun;239(2):251-67. doi: 10.1113/jphysiol.1974.sp010567.

Abstract

1. Isoprenaline hydrochloride injected subcutaneously or infused intravenously caused drinking and simultaneous antidiuresis in the dog. The minimal effective dose was between 20 and 50 mug per dog.2. Isoprenaline-induced drinking was prevented by the beta-adrenergic antagonist propranolol and enhanced by the alpha-antagonist phentolamine.3. Ganglionic blockade with pentolinium or with hexamethonium did not interfere with the response.4. A delay of 1 hr after injection of 100 mug isoprenaline, before drinking was permitted, did not significantly reduce the amount of water subsequently drunk. A preload of water approximately equal to the volume of water normally drunk caused a greater reduction in water intake in some dogs.5. Isoprenaline caused an increase in heart rate and pulse pressure which lasted for between 1 and 3 hr according to dose. Central venous pressure fell, but mean arterial pressure was little altered. Haemodynamic changes preceded drinking by about 5 min.6. Infusion of isoprenaline caused drinking in the bilaterally nephrectomized dog.7. We conclude that isoprenaline is a potent stimulus to drinking in the dog and that the effect is not exclusively mediated by the renin-angiotensin system.

MeSH terms

  • Animals
  • Blood Pressure / drug effects
  • Central Venous Pressure / drug effects
  • Depression, Chemical
  • Diuresis / drug effects*
  • Dogs
  • Drinking Behavior / drug effects*
  • Female
  • Heart Rate / drug effects
  • Hexamethonium Compounds / pharmacology
  • Isoproterenol / pharmacology*
  • Male
  • Nephrectomy
  • Pentolinium Tartrate / pharmacology
  • Phentolamine / pharmacology
  • Propranolol / pharmacology
  • Pulse / drug effects
  • Stimulation, Chemical

Substances

  • Hexamethonium Compounds
  • Pentolinium Tartrate
  • Propranolol
  • Isoproterenol
  • Phentolamine