Cancer growth, response to treatment and survival time in mice: beneficial effect of the prostaglandin synthesis inhibitor flurbiprofen

Prostaglandins. 1979 Feb;17(2):179-91. doi: 10.1016/0090-6980(79)90037-6.

Abstract

Adult mice were injected subcutaneously with cells from a syngeneic metastasizing mammary cancer. Daily treatment with flurbiprofen starting before injection of the cancer cells reduced tumour growth and lengthened the survival of mice whose tumours were excised at 3 weeks. When low doses of radiotherapy and chemotherapy were given, additional treatment with flurbiprofen starting 25 days after injecting the cancer cells substantially inhibited tumour growth.

MeSH terms

  • Animals
  • Drug Evaluation, Preclinical
  • Female
  • Flurbiprofen / therapeutic use*
  • Male
  • Mammary Neoplasms, Experimental / drug therapy*
  • Mammary Neoplasms, Experimental / metabolism
  • Mammary Neoplasms, Experimental / radiotherapy
  • Mice
  • Neoplasm Metastasis
  • Neoplasm Recurrence, Local
  • Neoplasm Transplantation
  • Propionates / therapeutic use*
  • Prostaglandin Antagonists*
  • Prostaglandins / biosynthesis

Substances

  • Propionates
  • Prostaglandin Antagonists
  • Prostaglandins
  • Flurbiprofen