Relation between the major histocompatibility (B) locus and autoimmune thyroiditis in obese chickens

Science. 1974 Oct 18;186(4160):274-5. doi: 10.1126/science.186.4160.274.

Abstract

Obese strain chickens develop circulating autoantibodies to thyroglobulin and lymphocytic infiltration of their thyroids during aging. Two alleles, B(1) and B(4), are found with high gene frequency at the major histocompatibility (B) locus. Greater pathology and higher antibody titers are observed in B(1)B(1) and B(1)B(4) birds than in their B(4)B(4) siblings.

MeSH terms

  • Alleles
  • Animals
  • Autoantibodies / analysis
  • Autoimmune Diseases / genetics*
  • Autoimmune Diseases / pathology
  • Chickens
  • Crosses, Genetic
  • Gene Frequency
  • Genes*
  • Genotype
  • Histocompatibility*
  • Lymphocytes
  • Thyroglobulin / immunology
  • Thyroiditis / genetics*
  • Thyroiditis / immunology
  • Thyroiditis / pathology

Substances

  • Autoantibodies
  • Thyroglobulin