Immunity of cholera in man: relative role of antibacterial versus antitoxic immunity

M M Levine; D R Nalin; J P Craig; D Hoover; E J Bergquist; D Waterman; H P Holley; R B Hornick; N P Pierce; J P Libonati

doi:10.1016/0035-9203(79)90119-6

Immunity of cholera in man: relative role of antibacterial versus antitoxic immunity

Trans R Soc Trop Med Hyg. 1979;73(1):3-9. doi: 10.1016/0035-9203(79)90119-6.

Authors

M M Levine, D R Nalin, J P Craig, D Hoover, E J Bergquist, D Waterman, H P Holley, R B Hornick, N P Pierce, J P Libonati

PMID: 442179
DOI: 10.1016/0035-9203(79)90119-6

Abstract

Purified cholera toxoid is antigenic when given enterally and orally. Purified toxoid fails to provide protection against experimental challenge. Clinical cholera confers formidable protection against homologous or heterologous rechallenge. Failure to culture vibrios from intestinal fluid or stool of re-challenge volunteers suggests that the predominant immune mechanism is antibacterial rather than antitoxic.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Antibodies, Bacterial / analysis
Antitoxins / analysis
Cholera / immunology*
Cholera / prevention & control
Cholera Toxin / administration & dosage
Cholera Toxin / immunology
Humans
Immunization Schedule
Immunoglobulins / analysis
Intestinal Secretions / immunology
Vibrio cholerae / immunology

Substances

Antibodies, Bacterial
Antitoxins
Immunoglobulins
Cholera Toxin