A vascular necrosis of the femoral head in childhood systemic lupus erythematosus

Can Med Assoc J. 1974 Oct 19;111(8):781-4.


Four of 10 children with SLE kept under observation over the past nine years have developed avascular necrosis (AN) of the femoral head. The symptoms of AN are insidious and unpredictable and predate the radiologic diagnosis by weeks to months. In a comparison of these children with SLE, with and without AN, with a group of patients with nephrosis treated with corticosteroids and a group with glomerulonephritis treated with azathioprine, AN was related to the duration of daily steroid therapy rather than the total duration of steroid treatment; this was not true for azathioprine. The occurrence of AN in our patients while they were on alternate-day steroid therapy, or coincident with a relapse, suggests that its development is determined by underlying disease.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Azathioprine / administration & dosage
  • Azathioprine / therapeutic use
  • Child
  • Corticosterone / administration & dosage
  • Corticosterone / therapeutic use
  • Female
  • Femur Head / diagnostic imaging
  • Femur Head Necrosis / diagnostic imaging
  • Femur Head Necrosis / drug therapy
  • Femur Head Necrosis / etiology*
  • Glomerulonephritis / drug therapy
  • Humans
  • Lupus Erythematosus, Systemic / complications*
  • Lupus Erythematosus, Systemic / diagnosis
  • Lupus Erythematosus, Systemic / diagnostic imaging
  • Lupus Erythematosus, Systemic / drug therapy
  • Prednisone / administration & dosage
  • Prednisone / therapeutic use
  • Radiography
  • Recurrence
  • Time Factors


  • Azathioprine
  • Prednisone
  • Corticosterone