Blockade of heart 3H-norepinephrine up-take by 4-phenyl-1-aminotetralines: implications for the active conformation of imipramine-like drugs

J Pharmacol Exp Ther. 1974 Dec;191(3):393-402.
No abstract available

MeSH terms

  • Amines / administration & dosage
  • Amines / pharmacology
  • Animals
  • Body Temperature / drug effects
  • Crystallography
  • Depression, Chemical
  • Desipramine / pharmacology
  • Dose-Response Relationship, Drug
  • Imipramine*
  • Male
  • Mice
  • Molecular Conformation
  • Myocardium / metabolism*
  • Naphthalenes / administration & dosage
  • Naphthalenes / pharmacology*
  • Norepinephrine / antagonists & inhibitors
  • Norepinephrine / metabolism*
  • Rats
  • Reserpine / antagonists & inhibitors
  • Reserpine / pharmacology
  • Stereoisomerism
  • Structure-Activity Relationship
  • Time Factors
  • Tritium

Substances

  • Amines
  • Naphthalenes
  • Tritium
  • Reserpine
  • Imipramine
  • Desipramine
  • Norepinephrine