Development and reversal of a proteoglycan aggregation defect in normal canine knee cartilage after immobilization

Arthritis Rheum. 1979 May;22(5):508-17. doi: 10.1002/art.1780220511.


Healthy adult dogs were studied for a defect in proteoglycan aggregation by immobilizing one limb for varying periods of time. Immobilization for 6 days resulted in a 41% reduction in proteoglycan synthesis by articular cartilage from the restrained knee compared with the contralateral control knee. After 3 weeks of immobilization, proteoglycan aggregation was no longer demonstrable in cartilage from the constrained limb. The aggregation defect was rapidly reversible and aggregates were again normal size 2 weeks after removal of a cast that had been worn for 6 weeks.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cartilage Diseases / etiology*
  • Cartilage Diseases / metabolism
  • Cartilage Diseases / pathology
  • Cartilage, Articular / metabolism*
  • Cartilage, Articular / pathology
  • Centrifugation, Density Gradient
  • Chromatography, Gel
  • Dogs
  • Immobilization*
  • Knee Joint* / metabolism
  • Knee Joint* / pathology
  • Proteoglycans / biosynthesis
  • Proteoglycans / isolation & purification
  • Proteoglycans / metabolism*
  • Time Factors


  • Proteoglycans